X-ray emission of radio-loud quasar SDSS J121426.52+140258.9: independent variations between optical/UV and X-ray emission

To understand the X-ray emission of active galactic nuclei (AGNs), we explored the optical-to-X-ray variation correlation of a radio-loud quasar (RLQ) SDSS J121426.52+140258.9 (hereafter J1214+1402) with multi-epoch observations of Swift and XMM-Newton telescopes. With the historical multi-band data, we found that the infrared to X-ray flux of RLQ J1214+1402 should not be dominated by the beamed jet emission. The Swift optical/UV and X-ray light curves showed that J1214+1402 has two optical states with low flux before 2014 April 08 and high flux after 2014 June 11, but has no significant X-ray variations during the time range between 2007 March 09 and 2014 August 04. This result was supported by the XMM-Newton observations in the overlapped time with Swift. Interestingly, the early XMM-Newton data prior to the Swift time presents two unusual emission epochs when J1214+1402 has relatively low optical fluxes but has the brightest X-ray fluxes. The overall independence of optical-to-X-ray variation seems hard to be described by the disk-corona model. With the X-ray spectral fitting, we find that the soft X-ray excess in J1214+1402 appears only during the high optical state when the X-ray emission is at low state. The soft X-ray excess in J1214+1402 is difficult to be explained by the ionized accretion disk, instead, it may be related to the warm corona.Comment: 13 pages, 9 figures, accepted for publication in MNRA

The Effect of Calcium and Phosphorous on Growth, Feed Efficiency, Mineral Content and Body Composition of Brown Marbled Grouper (Epinephelus Fuscoguttatus) Juvenile

The objectives of this study were to know concentration of calcium (Ca) and posphorus (P) in feed for growth, feed efficiency, proximate composition of the body and mineral content of brown marbled grouper juvenile. The study was conducted in the Center for Brackiswater Aquaculture Development, Takalar with randomized completed design 6 x 3 with the treatment of Ca and P supplement in feed i.e., (A) the supplement of 0 g/kg Ca and 0 g/kg P, (B) the supplement of 6 g/kg Ca and 0 g/kg P, (C) the supplement of 0 g/kg Ca and 6 g/kg P, (D) the supplement of 6 g/kg Ca and 6 g/kg P, (E) the supplement of 12 g/kg Ca and 6 g/kg P, and (F) the supplement of 18 g/kg Ca and 6 g/kg P. The result showed that P supplement with doses of 6 g/kg and Ca of 0 g/kg in feed are significantly affects on relative growth, feed efficiency, proximate composition and mineral content of brown marbled grouper juvenile

Hardware-aware motion estimation search algorithm development for high-efficiency video coding (HEVC) standard

This work presents a hardware-aware search algorithm for HEVC motion estimation. Implications of several decisions in search algorithm are considered with respect to their hardware implementation costs (in terms of area and bandwidth). Proposed algorithm provides 3X logic area in integer motion estimation, 16% on-chip reference buffer area and 47X maximum off-chip bandwidth savings when compared to HM-3.0 fast search algorithm.Texas Instruments Incorporate

Transient pressure analysis of a volume fracturing well in fractured tight oil reservoirs

This research was supported by the Ministry of Land and Resources Special Geological Survey: Upper Paleozoic Marine Shale Gas Geological Survey in Yunnan, Guizhou, Guangxi Region (DD20160178), The Key Laboratory of Unconventional Petroleum Geology of Geological Survey of China Open Fund and the Major National R&D Projects: Study on the Test Method for Shale Structure and Composition at Different Scales with project number: 2016ZX05034-003-006.Peer reviewedPostprin

Exploring the relationship between lactate metabolism and immunological function in colorectal cancer through genes identification and analysis

Introduction: Metabolic dysregulation is a widely acknowledged contributor for the development and tumorigenesis of colorectal cancer (CRC), highlighting the need for reliable prognostic biomarkers in this malignancy.Methods: Herein, we identified key genes relevant to CRC metabolism through a comprehensive analysis of lactate metabolism-related genes from GSEA MsigDB, employing univariate Cox regression analysis and random forest algorithms. Clinical prognostic analysis was performed following identification of three key genes, and consistent clustering enabled the classification of public datasets into three patterns with significant prognostic differences. The molecular pathways and tumor microenvironment (TME) of these patterns were then investigated through correlation analyses. Quantitative PCR was employed to quantify the mRNA expression levels of the three pivotal genes in CRC tissue. Single-cell RNA sequencing data and fluorescent multiplex immunohistochemistry were utilized to analyze relevant T cells and validate the correlation between key genes and CD4+ T cells.Results: Our analysis revealed that MPC1, COQ2, and ADAMTS13 significantly stratify the cohort into three patterns with distinct prognoses. Additionally, the immune infiltration and molecular pathways were significantly different for each pattern. Among the key genes, MPC1 and COQ2 were positively associated with good prognosis, whereas ADAMTS13 was negatively associated with good prognosis. Single-cell RNA sequencing (scRNA-seq) data illustrated that the relationship between three key genes and T cells, which was further confirmed by the results of fluorescent multiplex immunohistochemistry demonstrating a positive correlation between MPC1 and COQ2 with CD4+ T cells and a negative correlation between ADAMTS13 and CD4+ T cells.Discussion: These findings suggest that the three key lactate metabolism genes, MPC1, COQ2, and ADAMTS13, may serve as effective prognostic biomarkers and support the link between lactate metabolism and the immune microenvironment in CRC